Haematology - Dr Arun Subramaniyan

1 Anemia

Microcytic
- TAILS
  - Thalassemia ->Download
  - Anemia of Chronic Disease
  - Iron Deficiency anemia >Download
  - Lead poison
  - Sideroblastic anemia
Normocytic
- Decreased Production
  - Aplastic anemia
  - Anemia of Chronic Diseases
- Increased Hemolysis ( Hemolytic anemia)
  - Acquired (Extracorpuscular)
    - Immune ->Download
      - Autoantibody
        Warm Antibody
        Cold Antibody
      - Alloantibody
    - Non-Immune
      - Mechanical
      - Chemical / Physical
      - Infection
      - Acquired abnormal membrane ( Paroxysmal Nocturnal Hemoglobinuria)
  - Heridatory (Intracorpuscular)
    - Red Cell Membrane
      - Hereditary Spherocytosis ->Download
      - Hereditary Elliptocytosis
      - Hereditary Stomatocytosis
    - Enzyme Deficiencies
      - G6PD ->Download
      - Pyruvate Kinase
    - Hemoglobinopathies
      - Sickle Cell anemia ->Download
      - Thalassemia
Macrocytic
- FAT RBC MD
  - F- Folate
  - A-Alcohol
  - T- Hypothyroid
  - R- Retculocytosis
  - B- B12 Deficiency
  - C- Cirrhosis
  - M- Myelodysplasia
  - D- Drugs

2 HAEMATOLOGICAL CANCER

Leukemia->Download
- Acute Leukemia
  - Acute Myeloid leukemia (AML)
  - Acute Lymphoblastic Leukemia (ALL)
- Chronic Leukemia
  - Chronic Myeloid Leukemia (CML)
  - Chronic Lymphocytic Leukemia (CLL)
  - Hairy Cell Leukemia
Lymphoma ->Download
- Hodgkin Lymphoma
- Non Hodgkin Lymphoma
Plasma Celll Dyscrasias (Paraproteinemia)
- Multiple Myeloma
- Monoclonal Gammopathy of Undetermined Significance
- Waldenstrom Macroglobulinemia
Myeloproliferative neoplasm
- Essential thrombocythaemia
- Polycythemic rubra vera
- Myelofibrosis

3 CLOTTING DISORDERS

Bleeding Disorders ( Decreased Clots)
- Disorders of Primary hemostasis
  - Vessel wall abnormalities
    - Heridatory Haemorrhagic telangiectasia
    - Ehlers Danlos Disease
    - Scurvy
  - Platelet function disorders
    - Thrombocytopenia ->Download
- Disorders of Secondary Hemostasis (Coagulation Disorders) ( Hypocoagulable disorders)
  - Hemophilia A & Hemophilia B ( Christmas Factor) ->Download
  - Von Willebrand Disease
  - Rare Inherited bleeding disorders
  - Acquired Bleeding disorders
    - Liver Disease
    - Renal Failure
Thrombotic Disorders (Increased Clots)
- Venous Thromboembolic disease
- Thrombophilia (Hypercoagulable disorders)
  - Inherited
    - 1 Antithrombin deficiency
    - 2 Protein C and S deficiency
    - 3 Factor V Leiden
    - 4 Prothrombin G20210A
  - Acquired
    - Antiphospholipid Syndrome ->Download
    - Disseminated Intravascular Coagulation
    - Thrombotic Thrombocytopenic purpura